Macron, 39, beat far-right National Front (FN) candidate Marine Le Pen, 48, in an election that will have widespread repercussions for the future of Europe.
He has previously stated he will not give Britain an easy Brexit deal and even branded the UK's departure from the EU 'a crime'.
But in a sign of widespread disillusionment, one in three voters abstained or cast a blank ballot.
Just 15 minutes after the exit polls were announced, Le Pen conceded and revealed she phoned Macron to 'congratulate' him on his election victory.
Later in the evening, Macron addressed thousands of his adoring supporters who had gathered at his election victory rally outside the Louvre in central Paris.
He walked across the sprawling historic courtyard to the music of Beethoven's 'Ode to Joy', the European Union anthem, and said: 'Europe and the world are waiting for us to defend the spirit of the enlightenment everywhere.'
Addressing the jubilant crowd with a beaming smile, he said: 'Thank you my friends. Thank you for being here tonight. You have fought with courage.
'What we have done for so many months, everyone thought it was impossible, but they didn't know France. I thank you for your trust. Thank you for the risk some have taken.'
Macron also addressed those who had voted for Le Pen, telling the crowd: 'They have expressed today anger.
'I respect them and I will do everything in the five years that come for there to be no reason to vote for extremists. Today there are just the French. France reunited.'
He repeatedly said the task before him was 'immense' adding that Europe and the world were looking to France. He added that he would work to 'reform our Europe'.
Macron said that France had 'chosen audacity' and promised to serve his country with 'humility and strength'.
He added last night: 'This evening it is Europe and it is the world that are watching us. Europe and the world are waiting for us to defend the spirit of the enlightenment everywhere, threatened in so many places.
'They expect us to defend liberties everywhere, that we protect the oppressed. They are waiting for us to have a new hope, a new humanism, a more secure world, a world of freedom, a world of more growth, more justice, more ecology. They await us finally.
'The task before us is immense and will begin tomorrow (Monday). It will require making public life more responsible, defending our democratic values, strengthening our economy, building the new protections of this world around us, giving a place to everyone, rebuilding our Europe and ensuring the safety of all the French.'
He ended his speech with the immortal French words: 'Long live the Republic, long live France'.
During the campaign, Le Pen had hoped that the surprise election of Donald Trump in America, and the Brexit result in the UK, would favour her hardline opposition to the EU, globalisation and immigration.
But instead it was Macron who celebrated in front of crowds of supporters outside the Louvre in central Paris.